Analysis on the situation of human resource flow for centers of disease control and prevention in China / 上海预防医学

Objective To propose the policy recommendations to optimize the construction of human resources in centers for disease control and prevention , thus promoting the healthy development of China’s disease control and prevention undertaking . Methods The data between 2011 and 2015 from China Health Yearbook and China Yearbook of Health and Family Planning Statistics together with the monitoring, evaluation and investigation data from the long-term plan for health talents were utilized for making quantitative analyses;3 representative provinces were selected for making qualitative interviews . Results Between 2010 and 2014 , the average annual growth rate for the number of personnel in disease control and prevention centers was -0.40%.The average annual growth rate for the number of health technical personnel was -0 .87%, and that for the number of practicing/assistant physicians was-2.36%. Conclusion The loss of professional cores does occur in the human resources for disease prevention and control in China .The construction of the human resources for disease prevention and control shall be effectively strengthened and relevant measures shall be taken to attract and retain related technical specialists and talents .

Methylation in Promoter Region of SLC6A2 Gene in Heart Failure Patients and Its Correlation with Qi Deficiency/Blood Stasis Syndrome / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To explore the methylation status in promoter region of norepinephrine transporter gene (NET, SLC6A2) in heart failure ( HF) patients and its correlation with qi deficiency/blood stasis syndrome (QDS/BSS).</p><p><b>METHODS</b>Thirty-six patients with heart failure (NYHA classification III to IV) were recruited in the study (as the heart failure group) and their scores of QDS/BSS were evaluated. Besides, a healthy elderly group (30 cases) and a healthy youth group (30 cases) were also set up. They were recruited from Physical Examination Center of Fujian Provincial Hospital. Pyrosequencing was applied to detect the methylation in promoter region of SLC6A2 gene, and the total methylation index (MTI) of CpG island was calculated. The correlation between the methylation status in promoter region of SLC6A2 and scores of QDS/BSS was assessed using Pearson and Partial analyses. Risk factors were screened and adjusted using Logistic regression.</p><p><b>RESULTS</b>By one-factor analysis of variance, the total MTI in the HF group (219.72% ± 54.03%) was obviously higher than that in the healthy elderly group (194.47% ± 34.92%) and the healthy youth group (161.60% ± 41.11%) (all P < 0.05). Meanwhile, the total MTI was higher in the healthy elderly group than in the healthy youth group (P < 0.01). By covariance analysis , after controlling age and BMI, the total MTI was higher in the HF group than in the healthy elderly group (P = 0.041), while it was higher in the healthy elderly group than in the healthy youth group (P = 0.016). Age was found to play an essential role in affecting MTI of SLC6A2 gene promoter region among the 3 groups (F = 16.447, P = 0.01). The total MTI was quite lower in the healthy youth group. Results of Partial correlation analysis showed MTI was positively correlated with scores of qi deficiency and blood stasis respectively (r = 0.494 and 0.419 respectively, both P < 0.05). Logistic regression analysis showed after adjusting confounding factors, the relative risk (OR value) of total MTI of SLC6A2 gene in promoter region was 1.038 (95% CI, 1.006 to 1.071, P = 0.020).</p><p><b>CONCLUSIONS</b>Abnormally elevated methylation of the promoter region of SLC6A2 gene is one of risk factors for HF. In addition, the degree of methylation of the promoter region of SLC6A2 gene was positively correlated with the severity of QDS/BSS.</p>

Comparison of two surgical approach for cardiac cancer / 中华外科杂志

<p><b>OBJECTIVE</b>To explore the preferable surgical approach for cardiac cancer.</p><p><b>METHODS</b>One hundred and sixty patients with cardiac cancer underwent operation in two surgical approaches (epigastrium and left chest). Analysis was conducted on lymph nodes resected, stump positive rate, radical resectability rate, perioperative mortality, surgical complication rate, postoperative hospital days, survival rate between the two groups.</p><p><b>RESULTS</b>In the epigastrium group and the left chest group the average number of resected lymph nodes was 15.7 and 10.6, respectively, the upper stump positive rate was 5.0% and 1.2%, and there was significant difference between the two groups (P < 0.05). The lower stump positive rate, perioperative mortality, radical resectability rate, surgical complication rate, postoperative hospital days, survival rate of the two groups were 1.2%, 0.0%, 81.2%, 10.0%, 10 d, 53.7% and 1.2%, 1.2%, 83.7%, 11.2%, 12 d, 56.2%, respectively, and there was no significant difference between the two groups (P > 0.05).</p><p><b>CONCLUSION</b>There was no difference on the radical respectability rate and 5-year survival rate between the two groups. Thus the surgical approaches for cardiac cancer should based on the location and extent of lesions and the state of patients.</p>